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Allen, B.R., Lakhanpaul, M., Morris, A., Lateo, S., Davies, T., Scott, G., Cardno, M., Ebelin, M.E., Burtin, P. and Stephenson, T.J. (2003) Systemic Exposure, Tolerability, and Efficacy of Pimecrolimus Cream 1% in Atopic Dermatitis Patients. Archives of Disease in Childhood, 88, 969-973.
http://dx.doi.org/10.1136/adc.88.11.969

has been cited by the following article:

• TITLE: Treatment of Localized Vitiligo with 1% Pimecrolimus Cream versus 0.05% Clobetasol Propionate Cream—Single, Blinded, Comparative Therapeutic Trial

  AUTHORS: Khalifa E. Sharquie, Hayder R. Al-Hamamy, Adil A. Noaimi, Kholod A. Ali

  KEYWORDS: Localized Vitiligo, Pimecrolimius, Clobetasol Propionate

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.5 No.2, June 12, 2015

  ABSTRACT: Background: Calcineurin inhibitors like tacrolimus and pimecrolimus are new modality of treatment of localized vitiligo. Objective: To compare the effectiveness and side effects of 1% pimecrolimus cream in comparison with 0.05% clobetasol propionate cream as a treatment of localized type of vitiligo. Patients and Methods: Fifty two patients with localized vitiligo were included in this single, blind, comparative therapeutic trial. Full history and examination for each patient was done. Wood’s light was used when needed to confirm the diagnosis. Thirty (57.7%) were females and 22 (42.3%) males, female to male ratio of 1.36:1. Their ages ranged between 3 - 40 (13.15 ± 7.9) years, while disease duration ranged from 6 - 84 (29.62 ± 20.56) months. Total numbers of lesions were 114 lesions with a mean of 2.2 lesions per patient. The surface area of the lesions ranged between 1 - 31 (7.15 ± 6.98) cm2. Vitiliginous patches were most commonly located on face 48 (42.1%) lesions, and lower limbs 35 (30.7%) lesions. Patients were divided in to two groups according to the type of therapeutic modality.GroupAconsisted of 25 patients (52 lesions) receiving 1% pimecrolimus cream andGroupB27 patients (62 lesions) treated with 0.05% clobetasol propionate cream, both used twice daily. The amount of cream per area was applied according to rule of fingertip unit. Measuring the surface area of the lesions and calculating the reduction rate were done every month till the end of the 6thmonth. Then patients were asked to stop the use of medication to be re-evaluated again after 3 months without any treatment and to record any local or systemic side effects. Results: After 6 months of treatment there was 79.67% reduction in the surface area of lesions inGroupA, while inGroupBthere was 82.59% reduction in the surface area with no statistically significant difference between the two groups. The reduction rate was early as there was statistically significant reduction for both groups after one month of treatment (p value