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has been cited by the following article:

• TITLE: Comparative Epigenetic Analyses of Acute and Chronic Leukemia

  AUTHORS: Yan Zhang, Dianjing Guo

  KEYWORDS: Leukemia, Epigenetics, Histone Modification, Promoter

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.3 No.6, June 12, 2015

  ABSTRACT: Comparative analysis of epigenetic alterations between acute vs. chronic leukemia, with an emphasis on histone modifications, was conducted. We focus on the promoter regions of the whole genomes as well as oncogenes. Our results revealed that obvious differential histone modifications pattern exists between the two subtypes. H3K27ac has a high tag density in the promoter region in both Dnd41 cell lines and K562 cell lines. H3K27ac and H3K4me1 have high correlation between the two cell lines of oncogenes. Similar results were also achieved in the promoter region of high expression genes in the Jurkat and K562 cell lines based on RNA-seq data. This suggests that H2K27ac and H3K4me1 are active regulators in leukemia cell lines.