TITLE:
A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis
AUTHORS:
Masao Sugamata, Tomomi Ihara, Ichiro Uchiide
KEYWORDS:
Endometriosis, Leukotriene Receptor, Apoptosis, r-AFS Score, Infertility
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.6,
June
10,
2015
ABSTRACT: Some drugs that regulate estrogen are currently used as therapy for
endometriosis. However, these medical treatments have significant side effects
and patients who hope to become pregnant cannot overcome infertility. To
compare morphological alterations and clinical symptoms, revised American
Fertility Society (r-AFS) scores were compared between patients with and
without leukotriene receptor antagonist (LTR-A) treatment. LTR-A-treated cases
showed significantly decreased r-AFS score. Furthermore, a significant
correlation was seen between r-AFS score and LTR-A treatment period. In treated cases, clinical symptoms decreased and
some patients achieved pregnancy. Morphologically, lesions in
LTR-A-treated cases showed apoptotic fibroblasts and degeneration of collagen
fibers. Our findings revealed that LTR-As had significant therapeutic value for
the treatment of human endometriosis. Anti-LT therapy appears efficacious not
only in the treatment of clinical symptoms and lesions, but also in improving
fertility.