TITLE:
The Content of Silver, Cobalt, Chromium, Iron, Mercury, Rubidium, Antimony, Selenium, and Zinc in Osteogenic Sarcoma
AUTHORS:
Sofia Zaichick, Vladimir Zaichick
KEYWORDS:
Trace Elements, Human Bone, Osteogenic Sarcoma, Neutron Activation Analysis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.6,
June
3,
2015
ABSTRACT: Objectives: To clarify the role of trace elements in the etiology and the
pathogenesis of the osteogenic sarcoma (osteosarcoma), a non-destructive
neutron activation analysis with high resolution spectrometry of long-lived
radionuclides was performed. Methods: The silver (Ag), cobalt (Co), chromium
(Cr), iron (Fe), mercury (Hg), rubidium (Rb), antimony (Sb), selenium (Se), and zinc (Zn) mass fraction, Rb/Co,
Rb/Fe, Rb/Se, and Rb/Zn mass fraction ratios as well as Co × Zn, Fe × Zn, Sb × Zn,
Se × Zn, Co × Se, and Fe × Se mass fraction multiplications were estimated in
normal bone samples from 27 patients with intact bone (12 females and 15 males,
aged from 16 to 49 years), who had died from various non bone related causes,
mainly unexpected from trauma, and in tumor samples, obtained from open
biopsies or after operation of 27 patients with osteosarcoma (9 females and 18
males, 6 to 71 years old). The reliability of difference in the results between
intact bone and osteosarcoma tissues was evaluated by Student’s t-test. Results: In the osteosarcoma tissue
the mass fractions of Co, Cr, Fe, Sb, Se, and Zn are significantly higher while
the mass fraction of Rb is lower than in normal bone tissues. Moreover, we
found significantly lower values of Rb/Co, Rb/Fe, Rb/Se, and Rb/Zn mass
fraction ratios as well as significant higher mean values of Co × Zn, Fe × Zn,
Sb × Zn, Se × Zn, Co × Se, and Fe × Se mass fractions multiplications in the
osteosarcoma tissue compared to intact bone. In the osteosarcoma tissue many
correlations between trace elements found in the control group were no longer
evident. Conclusion: In osteosarcoma transformed bone tissues the trace element
homeostasis is significantly disturbed.