Article citationsMore>>
Kehoe, P.G., Williams, H., Holmans, P., Wilcock, G., Cairns, N.J., Neal, J. and Owen, M.J. (1998) The Butyrylcholinesterase K Variant and Susceptibility to Alzheimer’s Disease. Journal of Medical Genetics, 35, 1034-1035.
http://dx.doi.org/10.1136/jmg.35.12.1034
has been cited by the following article:
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TITLE:
Prevalence of Wild-Type Butyrylcholinesterase Genotype in Patients with Alzheimer’s Dementia
AUTHORS:
Beate Mueller, Georg Adler
KEYWORDS:
Butyrylcholinesterase, Alzheimer’s Disease, Genotype
JOURNAL NAME:
World Journal of Neuroscience,
Vol.5 No.3,
June
2,
2015
ABSTRACT: Approximately, two-thirds patients
with Alzheimer’s disease (AD) are reported to have homozygous wild-type
butyrylcholinesterase (BuChE) gene expression. It is associated with a higher
rate of hydrolysis of acetylcholine, which ultimately leads to increase in the
levels of BuChE in advanced stages of the disease. Rivastigmine, a dual
inhibitor of acetylcholinesterase (AChE) and BuChE, might be of additional
benefit in patients with AD with wild-type BuChE allele.