TITLE:
Prevalence of Wild-Type Butyrylcholinesterase Genotype in Patients with Alzheimer’s Dementia
AUTHORS:
Beate Mueller, Georg Adler
KEYWORDS:
Butyrylcholinesterase, Alzheimer’s Disease, Genotype
JOURNAL NAME:
World Journal of Neuroscience,
Vol.5 No.3,
June
2,
2015
ABSTRACT: Approximately, two-thirds patients
with Alzheimer’s disease (AD) are reported to have homozygous wild-type
butyrylcholinesterase (BuChE) gene expression. It is associated with a higher
rate of hydrolysis of acetylcholine, which ultimately leads to increase in the
levels of BuChE in advanced stages of the disease. Rivastigmine, a dual
inhibitor of acetylcholinesterase (AChE) and BuChE, might be of additional
benefit in patients with AD with wild-type BuChE allele.