TITLE:
FeCl3 Catalyzed One Pot Synthesis of 1-Substituted 1H-1,2,3,4-Tetrazoles under Solvent-Free Conditions
AUTHORS:
Fatemeh Darvish, Shima Khazraee
KEYWORDS:
Iron(III) Chloride, 1-Substituted-1H-1, 2, 3, 4-Tetrazoles, Amines, Triethyl Orthoformate, Solvent-Free, Trimethylsilyl Azide
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.5 No.2,
June
3,
2015
ABSTRACT: An efficient procedure for the preparation of 1-substituted-1H-1,2,3,4-tetrazoles via a three-component condensation of triethyl orthoformate, amine, and trimethylsilyl azide using inexpensive and environment-friendly FeCl3 as catalyst under solvent-free conditions has been reported. The reaction generates the corresponding 1-substituted tetrazole in excellent yields.