TITLE:
From Russia with Polyuria
AUTHORS:
DaLim Ki, Udaya M. Kabadi
KEYWORDS:
Polyuria, Urine Osmolarity, Nephrogenic Diabetes Insipidus, Demeclocycline
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.5 No.5,
May
28,
2015
ABSTRACT: Introduction: Polyuria is a sign for many disease processes, including
diabetes mellitus and diabetes insipidus. Urine osmolarity helps distinguish
osmotic diuresis caused by diabetes mellitus from water dieresis induced by
diabetes insipidus. Case Presentation: We report a case of a 48-year-old woman who
presented with polyuria, polydipsia, nocturia, and weight loss after a return
from a visit to Russia, during which she received a five-day course of
antibiotic Demeclocycline, a tetracycline derivative for dental treatment. She recovered
from all clinical manifestations by 8 weeks. Conclusion: Manifestation of
transient nephrogenic diabetes insipidus is induced by Demeclocycline.