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Lin, J. and Denker, B.M. (2012) Chapter 44. Azotemia and Urinary Abnormalities. In: Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson, J. and Loscalzo, J., Eds., Harrison’s Principles of Internal Medicine, McGraw-Hill, New York, 18e.

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• TITLE: From Russia with Polyuria

  AUTHORS: DaLim Ki, Udaya M. Kabadi

  KEYWORDS: Polyuria, Urine Osmolarity, Nephrogenic Diabetes Insipidus, Demeclocycline

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.5 No.5, May 28, 2015

  ABSTRACT: Introduction: Polyuria is a sign for many disease processes, including diabetes mellitus and diabetes insipidus. Urine osmolarity helps distinguish osmotic diuresis caused by diabetes mellitus from water dieresis induced by diabetes insipidus. Case Presentation: We report a case of a 48-year-old woman who presented with polyuria, polydipsia, nocturia, and weight loss after a return from a visit to Russia, during which she received a five-day course of antibiotic Demeclocycline, a tetracycline derivative for dental treatment. She recovered from all clinical manifestations by 8 weeks. Conclusion: Manifestation of transient nephrogenic diabetes insipidus is induced by Demeclocycline.