TITLE:
Purple Grape Juice, an Important Flavonoids Source, Influence in Biochemical Parameters in Offspring of Wistar Rats
AUTHORS:
Daniele Karina Hilger, Mariane Farias Wohlenberg, Thays Krischke Schaffer, Fernanda de Souza Machado, Luciana Kneib Gonçalves, Gabrielli Bortolato, Gabriele Dani, Adriana Rodrigues, Cláudia Funchal, Caroline Dani
KEYWORDS:
Vitis labrusca, Biochemical Profile, Pregnancy, Grape Juice
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.6 No.7,
May
25,
2015
ABSTRACT: Our objective was to evaluate the effect of chronic gestational treatment and post-breast feeding with purple grape juice on the biochemical parameters in offspring of dams. We used 40 male offspring from 14 Wistar rats which received purple grape juice or water by gavage daily for 42 days at a dose of 7 microliters/g. The offspring were divided into groups of water or juice. All received daily purple grape juice or water by gavage for 30 days after completion of their nursing period at a dose of 7 microliters/g. At the end of the treatment period, the offspring were euthanized by decapitation with its truncal blood collected and subsequently separated the serum from the blood. The measurements were performed by automation or by manual dosing. Considering the gestational factor, grape juice was able to reduce levels of total cholesterol, triglycerides, urea, alanine aminotransferase (ALT), and not alter the levels of creatinine and aspartate aminotransferase (AST) in serum of the offspring. When considering the post-breast feeding factor, grape juice resulted in an improvement in HDL-C. We concluded that purple grape juice was able to produce a beneficial effect on certain biochemical parameters in offspring.