Article citationsMore>>

Ijichi, S., Ijichi, N., Ijichi, Y., Sameshima, H. and Morioka, H. (2011) The Genetic Basis of Phenotypic Diversity: Autism as an Extreme Tail of a Complex Dimensional Trait. In: Deutsch, S., Ed., Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment, InTech, Rijeka, 83-102. http://dx.doi.org/10.5772/19032 http://www.intechopen.com/download/pdf/17279

has been cited by the following article:

• TITLE: The Origin of Population Diversity: Stochastic Interactions between a Modifier Variant and the Individual Genetic Background

  AUTHORS: Shinji Ijichi, Naomi Ijichi, Yukina Ijichi, Junko Nagata, Chikako Imamura, Hisami Sameshima, Yoichi Kawaike, Hirofumi Morioka

  KEYWORDS: Population Diversity, Stochastic Epistasis, Human Complex Traits, Autism

  JOURNAL NAME: Natural Science, Vol.7 No.5, May 18, 2015

  ABSTRACT: Stochastic epistasis that is one of the characteristics of epistatic gene modules can have an important role in the maintenance of intraspecific population diversity. The effect of an epistatic modifier variant can vary in size and direction among the modifier careers on the basis of stochastic genetic individuality and the entire module effect can be also individually stochastic. This stochastic genetic contribution under a genetic background may be conditional upon the presence of a monomorphic switch locus in the gene module. The genetic background includes multiple modifier variants and the gene module is composed of the switch and the modifiers. The bell-shaped distribution of quantitative traits can be well simulated by the involvement of multiple stochastic epistatic modules. The phenotypic stochasticity makes the presence of switch and modifiers cryptic or missing in the research field and this cryptic gene networks can maintain and innovate in the phenotypic diversity under selection as a process of the evolution of complexity.