Article citationsMore>>

de Leeuw, F.E., de Groot, J.C., Oudkerk, M., Witteman, J.C., Hofman, A., van Gijn, J. and Breteler, M.M. (2012) Hypertension and Cerebral White Matter Lesions in a Prospective Cohort Study. Brain, 125, 765-772.
http://dx.doi.org/10.1093/brain/awf077

has been cited by the following article:

• TITLE: Could Ambulatory Blood Pressure Monitoring Be a Routine Investigation for Patients with Mild Cognitive Impairment?

  AUTHORS: Mohamed Hamdy Ibrahim, Tamer Taha Ismail Taha, Laila Adel Mohsen, Nisrin Moustafa Rizk El-Elsaadouni

  KEYWORDS: Mild Cognitive Impairment, Ambulatory Blood Pressure Monitoring, White Matter Lesions, Non-Dipper, MMSE

  JOURNAL NAME: Neuroscience and Medicine, Vol.6 No.2, May 15, 2015

  ABSTRACT: Objectives: To study the ambulatory measured blood pressure (ABPM) profile in normotensive patients with mild cognitive impairment (MCI). Patients and Methods: The study was designed as a case control study including 50male patients with mild cognitive impairment in the age group of 30 - 50 years old. The control group included 30 volunteers with no cognitive impairment and in the same age group (30 - 50 years old) and same gender. Mini-mental estate examination, office and ABP monitoring (ABPM) and brain MRI scans were done for cases and controls. Results: Thirty patients (60%) with MCI revealed a non-dipper blood pressure pattern. Sleeping systolic blood pressure and sleeping systolic load were significantly higher in patients with MCI than in normal volunteers (p = 0.01). MRI brain showed more white matter lesions (WMLs) in patients with MCI than in normal volunteers; however, this didn’t reach significance level (p = 0.056). Conclusion: MCI in normotensive young adult patients could reflect an abnormal circadian blood pressure rhythm. Ambulatory blood pressure monitoring could be an essential investigation in young adult MCI patients.