Article citationsMore>>

Clark, P., Walker, I.D., Langhorne, P., Crichton, L., Thomson, A., Greaves, M., Whyte, S. and Greer, I.A., on Behalf of the Scottish Pregnancy Intervention Study (SPIN) Collaborators (2010) SPIN (Scottish Pregnancy Intervention) Study: A Multicenter, Randomized Controlled Trial of Low-Molecular Weight Heparin and Low-Dose Aspirin in Women with Recurrent Miscarriage. Blood, 115, 4162-4167.
http://dx.doi.org/10.1182/blood-2010-01-267252

has been cited by the following article:

• TITLE: Inherited Thrombophilia and Early Recurrent Pregnancy Loss among Egyptian Women

  AUTHORS: Omneya M. Osman, Nelly N. Abulata

  KEYWORDS: Thrombophilia, Recurrent Pregnancy Loss, Genetic Mutations, MTHFR

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.5 No.5, May 8, 2015

  ABSTRACT: Inherited thrombophilia has been implicated as a possible cause of recurrent pregnancy loss. Although numerous studies are available in literature, thrombophilia rate seems to vary fromstudy to another. The aim of our study was to determine the frequency of FII Prothrombin(G20210A), Factor V Leiden (G1691A), as well as methyl tetrahydrofolate reductase (MTHFRC677T) polymorphisms, protein C, protein S and antithrombin III deficiency in a series of patients with unexplained RPL compared to control. Patients and Methods: 100 patients of unexplained RPL and 43 age-matched healthy controls were investigated for inherited thrombophilia. Results: MTHFR and Factor V Leiden were the commonest gene defects among cases studied (63%, 60% respectively) and control groups (41.9%, 41.9% respectively) (p = 0.019, p = 0.046 respectively). The least common deficiencies were protein S and protein C deficiency in cases (3%, 2% respectively) as well as in controls (1%, 0% respectively). 4 cases were homozygous for MTHFR and 2 cases homozygous for Factor V Leiden mutation. Odds ratio for MTHFR and Factor V mutation was 2.36 and 2.08 respectively (CI 95%). Combined defects were seen in cases and controls (p