TITLE:
CNVs Associated with Susceptibility to Cancers: A Mini-Review
AUTHORS:
Tomoko Furuya, Yutaka Suehiro, Yukihisa Namiki, Kohsuke Sasaki
KEYWORDS:
CNV, Cancer Susceptibility, Carcinogenesis, Cancer, Genome, Genomic Polymorphism
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.5,
May
6,
2015
ABSTRACT: Copy number variations (CNVs) that are
frequent in genome influence on susceptibility of various diseases including
cancers. The present mini-review focuses on CNVs associated with susceptibility
to the cancers. Since CNVs are different between cancer types, the analysis of
the specific CNV makes it possible to estimate the susceptibility to the
cancers of interest in individuals. Although it is true that available data on
CNVs associated with cancer susceptibility are limited at present, accumulation
of the data is accelerated with the research progression of CNVs in near
future. Information on CNVs associated with cancer susceptibility is useful for
not only cancer research but also personalized healthcare including cancer
prevention.