TITLE:
Pathogenesis of Cancer: Cancer Reparative Trap
AUTHORS:
Oleg V. Bukhtoyarov, Denis M. Samarin
KEYWORDS:
Carcinogenesis, Cancer Pathophysiology, Anti-Tumor Immunity, Cancer Reparative Trap
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.5,
May
6,
2015
ABSTRACT: Cancer is one of the leading causes of
death in the world while the long-term prognosis is still unfavorable, despite
the enormous efforts in the search for effective anti-cancer drugs. We think
that the obstacle for creating of effective anti-cancer drugs could be existing
idea that the basis of cancer is caused by the damage of the genetic apparatus
of the cell. In this paper, we present the pathogenesis of cancer which is
based on the formation of the special sustainable pathophysiological state of
the organism what we call the state of “cancer reparative trap”. The essence of
this pathophysiological state of the organism is in the reparative orientation
of the immune system of cancer patients, when constant tissue repair is
accompanied by systemic suppression of the anti-tumor immunity. Specifically,
during the long-term exposure to carcinogens (exogenous and/or endogenous), the
continuous tissue damage occurs which induces permanent stimulation of cell
proliferation (imbalanced Th1 Th2 lymphocytes, M1 et al.), which
creates the necessary conditions for the survival of the malignantly
transformed cells, formed by the action of carcinogens. The determining role of
the imbalance in the autonomous nervous system (simpathetic/hypersympathetic
dominance) in the development, maintenance and generalization of the cancer
process has been shown. The explanation of a number of phenomena has been
presented: the cell resistance to chemotherapy, and the phenomenon of cancer
cell dormancy. The promising approaches for the cancer management in clinical
practice have been proposed.