TITLE:
Immunovirological and Biochemical Changes in Nigerian Patients with Hepatitis B Coinfection on Antiretroviral Therapy
AUTHORS:
Jesse Abiodun Otegbayo, Titilola Stella Akingbola, Joshua Odunayo Akinyemi, Kayode Solomon Adedapo, Georgina Njideka Odaibo, Yetunde Adebisi Aken Óva, David Olufemi Olaleye, Isaac Folorunsho Adewole, Robert Murphy, Phylis Kanki
KEYWORDS:
Hepatitis B, Coinfection, CD4, Viral Load, Antiretroviral, Nigeria
JOURNAL NAME:
World Journal of AIDS,
Vol.1 No.2,
June
30,
2011
ABSTRACT: Hepatitis B virus (HBV) co-infection with HIV is high among Nigerians. Some studies have suggested impaired CD4 recovery among coinfected patients compared to the HIV mono infected. This retrospective study of treatment-naïve HIV infected patients was aimed at determining the trend of changes in CD4+ counts, HIV-RNA and renal and liver function tests in response to combined antiretroviral therapy (CART). A questionnaire was utilised to extract clinical and laboratory data of HBV co infected HIV/AIDS patients before treatment and at six, twelve and eighteen months of therapy with CART. Findings were compared to those of HIV mono infected. Relevant statistical instruments were used to analyse for comparisons of means of Log10 HIV viral load and CD4 count using SPSS package 15.0. All levels of sig-nificance were at 5 %. Two thousand five hundred and sixty two patients were analysed. Of these, 354(13.8%) were HBsAg positive. Majority (63.1%) were females. Most of the recruited patients were on combivir and nevirapine. The median CD4 count for the HBsAg negative was 104 cells/mm3 (IQR 34 – 171) and it was significantly higher than those of the positive (91 cells/mm3) (p