TITLE:
Radiolanthanides Device Production
AUTHORS:
F. Monroy-Guzman, F. Jimenez Barreiro, E. Jaime Salinas, A. L. Vera Treviño
KEYWORDS:
149Pm, 161Tb, 166Ho, 177Lu, Production
JOURNAL NAME:
World Journal of Nuclear Science and Technology,
Vol.5 No.2,
April
28,
2015
ABSTRACT: 149Pm, 166Ho, 161Tb and 177Lu conjugated to chemical agents (monoclonal
antibodies, polypeptide, etc.) have the appropriate decay characteristics for
imaging and therapeutic studies and consequently the potential to be useful in
radiotherapy and diagnosis. These carrier-free radioisotopes can be produced by
neutron irradiation of a lanthanide target followed by β-decay, and a posterior
radiochemical separation of the daughter radionuclide from macro-amounts of the
parent target. In order to produce carrier free 149Pm, 161Tb, 166Ho and 177Lu for radiotherapy, with a radionuclide
purity of more than 99.9%, a device production was developed based on
separation of Nd/Pm, Gb/Tb, Dy/Ho and Yb/Lu by extraction chromatography.