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Winquist, E., Nabid, A., Sicheri, A., Ganguly, P., Venkatesan, V., Schneider, K., et al. (2002) A Phase I Dose Escalation Study of a Humanized Monoclonal Antibody to EGFR (hR3) in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN) Treated with Radiotherapy (RT). Proceedings of American Society of Clinical Oncology, 21, 926.

has been cited by the following article:

• TITLE: Nimotuzumab with Concurrent Chemo-Radiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of Head and Neck (LASCCHN)

  AUTHORS: Naresh Somani

  KEYWORDS: Nimotuzumab, Anti-Epidermal Growth Factor Receptor (Anti-EGFR), Chemotherapy, Radiotherapy, Locally Advanced Squamous Cell Carcinoma of Head and Neck (LASCCHN)

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.4, April 22, 2015

  ABSTRACT: Background: Head and neck cancers (HNCs) constitute 5% of all cancers globally and are the most common cancers in India. Chemotherapy and radiotherapy have not been proved to be effective in advanced cases and the prognosis remains dismal. This underscores the need for newer treatment options in these cases. Nimotuzumab, an anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibody, was safer when combined with chemo- or radio-therapy. Aim: To evaluate the safety and efficacy of concurrently administered nimotuzumab with chemo-radiotherapy in patients with advanced inoperable squamous cell carcinomas of head and neck (LASCCHN). Methods:This was an open-label, single arm study evaluating 57 patients with histologically confirmed inoperable LASCCHN (stages III and IV) and eastern co-operative oncology group (ECOG) performance status 2and IV nimotuzumab 200 mg weekly for 6 weeks, along with radiotherapy of 6600 cGy over 33 fractions. Patients were evaluated over response evaluation criteria in solid tumors (RECIST) criteria 24 weeks after the last cycle of chemotherapy. Results: Mean age of patient was 50 years old (29 - 79 years old). The most common site of cancer was oral cavity (56.1%). Forty six patients (80.7%) completed 6 cycles of therapy. Objective response rate (ORR) was 80.7%, with 34 patients (59.6%) achieving complete response (CR), and 12 (21%) achieving partial response (PR). Stable disease (SD) was noted in 8 (14%) patients and progressive disease in 3 (5.2%) patients. Conclusion: Addition of nimotuzumab is a safe and efficacious option in patients with inoperable LASCCHN. Our observations confirm the available Phase II data. The long term survival benefits based on this encouraging response rate need to be further evaluated in this subset of cancer patients.