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Khammassi, N., Kwas, H., Bayoudh, A., Abdelhedi, H., Zendah, I., Cherif, I., et al. (2014) Systemic Sarcoidosis Revealed by an Involvement of the Nasal Sinuses. La Tunisie Médicale, 92, 181-183.

has been cited by the following article:

• TITLE: Systemic Sarcoidosis Revealed by a Nasal Lesion: A Case Report

  AUTHORS: Madiha Mahfoudhi, Khaled Khammassi, Sami Turki, Mamia Ben Salah

  KEYWORDS: Sarcoidosis, Nose, Granuloma, Corticosteroids

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.6 No.4, April 16, 2015

  ABSTRACT: A 62-year-old man presented with bilateral nasal obstruction and recurrent epistaxis episodes. Physical examination revealed normal body temperature and free cervical lymph nodes areas. Nasal endoscopy found a congestive nasal mucosa associated to bilateral inferior turbinate hypertrophy with a granular aspect of the right inferior turbinate. The biological examination showed lymphopenia, inflammatory syndrome, high serum level of angiotensin-converting enzyme and β2 microglobulin. Tuberculin skin test and Quantiferon gold were negative. The nasal and accessory salivary gland biopsies revealed granulomatous giant cell lesions non-caseating evoking systemic sarcoidosis. Ziehl-Neelsen staining and Lowenstein culture were negative. The diagnosis was systemic sarcoidosis revealed by nasal localization. The systemic extension research was negative. The treatment was based on corticosteroids (1 mg/kg/day) and gradual degression doses associated to a local nasal corticosteroid. The outcome was favorable with improvement of nasal obstruction and disappearance of initial lesions. The follow-up was 2 years.