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Lodi, G., Tarozzi, M., Sardella, A., Demarosi, F., Cane- gallo, L., Di Benedetto, D. and Carrassi, A. (2007) Miconazole as adjuvant therapy for oral lichen planus: a double-blind randomized controlled trial. British Journal of Dermatology, 156, 1336-1341. doi:10.1111/j.1365-2133.2007.07883.x

has been cited by the following article:

• TITLE: Efficacy of IMOD in the treatment of oral lichen planus—Efficacy of IMOD in oral lichen planus

  AUTHORS: Farzaneh Agha-Hosseini, Iraj Mirzaii-Dizgah, Mohammad Abdollahi, Neda Akbari-Gillani

  KEYWORDS: Oral Lichen Planus; IMOD; TNF-α

  JOURNAL NAME: Open Journal of Stomatology, Vol.1 No.2, July 1, 2011

  ABSTRACT: Objectives: Oral lichen planus (OLP) is a chronic, immunologically mediated, mucocutaneous disorder. A wide range of topical and systemic therapies have been used in the treatment of OLP. The efficacy of IMOD (an Iranian new immunomodulator drug, con- taining selenium, carotene, and flavonoids) in the management of oral lichen planus was evaluated. Study design: In a before-after clinical trial study, thirty patients (21 women and 9 men; age range 35 - 66 years with 112 lesions) with lichen planus were enrolled. The study covered a three-month period of therapy by IMOD (400 mg/day) and a three-month follow-up period after drug cessation. Outcome mea- sures include soreness relief based on the “nu-meric scale”, and clinical improvement of lesion size and score. Saliva levels of TNF-α was analysed at the baseline and after treatment by ELISA. Statistical analysis of Wilcoxon and paired student’s t-test were used. Results: Approximately 85% of patients showed partial to complete improvement and re-mained sym- ptom free after drug cessation. There was no signifi-cant difference in mean saliva TNF-α level before and after the treatment. Conclusion: These results suggest that IMOD seems to be an effective alternative treat- ment for OLP and TNF-α may not be a good indica- tor for monitoring therapeutic response of OLP.