Article citationsMore>>
Gorouhi, F., Solhpour, A., Beitollahi, J.M., Afshar, S., Davari, P., Hashemi, P., Nassiri Kashani, M. and Firooz, A. (2007) Randomized trial of pimecrolimus cream versus triamcinolone acetonide paste in the treatment of oral lichen planus. Journal of the American Academy of Dermatology, 57, 806-813.
doi:10.1016/j.jaad.2007.06.022
has been cited by the following article:
-
TITLE:
Efficacy of IMOD in the treatment of oral lichen planus—Efficacy of IMOD in oral lichen planus
AUTHORS:
Farzaneh Agha-Hosseini, Iraj Mirzaii-Dizgah, Mohammad Abdollahi, Neda Akbari-Gillani
KEYWORDS:
Oral Lichen Planus; IMOD; TNF-α
JOURNAL NAME:
Open Journal of Stomatology,
Vol.1 No.2,
July
1,
2011
ABSTRACT: Objectives: Oral lichen planus (OLP) is a chronic, immunologically mediated, mucocutaneous disorder. A wide range of topical and systemic therapies have been used in the treatment of OLP. The efficacy of IMOD (an Iranian new immunomodulator drug, con- taining selenium, carotene, and flavonoids) in the management of oral lichen planus was evaluated. Study design: In a before-after clinical trial study, thirty patients (21 women and 9 men; age range 35 - 66 years with 112 lesions) with lichen planus were enrolled. The study covered a three-month period of therapy by IMOD (400 mg/day) and a three-month follow-up period after drug cessation. Outcome mea- sures include soreness relief based on the “nu-meric scale”, and clinical improvement of lesion size and score. Saliva levels of TNF-α was analysed at the baseline and after treatment by ELISA. Statistical analysis of Wilcoxon and paired student’s t-test were used. Results: Approximately 85% of patients showed partial to complete improvement and re-mained sym- ptom free after drug cessation. There was no signifi-cant difference in mean saliva TNF-α level before and after the treatment. Conclusion: These results suggest that IMOD seems to be an effective alternative treat- ment for OLP and TNF-α may not be a good indica- tor for monitoring therapeutic response of OLP.