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Saito, M., Kawana, J., Ohno, T., Kaneko, M., Mihara, K., Hanada, K., et al. (2006) Enantioselective and Highly Sensitive Determination of Carvedilol in Human Plasma and Whole Blood after Administration of the Racemate Using Normal-Phase High-Performance Liquid Chromatography. Journal of Chromatography B, 843, 73-77.
http://dx.doi.org/10.1016/j.jchromb.2006.05.018
has been cited by the following article:
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TITLE:
HPLC Method Development and Validation of S(-)-Carvedilol from API and Formulations
AUTHORS:
Ettireddy Swetha, Chandupatla Vijitha, Ciddi Veeresham
KEYWORDS:
S(-)-Carvedilol, Chiral HPLC, Chiral Resolution, API, Validation
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.6 No.5,
April
13,
2015
ABSTRACT: A simple chiral HPLC method was developed and validated for quantification of S(-)-Carvedilol in Active Pharmaceutical Ingredient (API) and marketed tablet formulation of racemic Carvedilol. Chiral resolution of enantiomers of Carvedilol was achieved on Phenomenex Lux-cellulose–4 (250 mm × 4.6 mm; 5 μ particle size) chiral column by using a mobile phase, Isopropanol and n-Heptane (60:40 v/v), at a flow rate of 1.0 ml/min and by employing UV detection at 254 nm wavelength. The method was validated according to the ICH guidelines and was proved to be specific, linear, precise and accurate for the analysis of S(-)-Carvedilol.