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Olas, B., Wachowicz, B., Nowak, P., Kedzierska, M., Tomczak, A., Stochmal, A., Oleszek, W., Jeziorski, A. and Piekarski, J. (2008) Studies on Antioxidant Properties of Polyphenol-Rich Extract from Berries of Aronia melanocarpa in Blood Platelets. Journal of Physiology and Pharmacology, 59, 823-835.

has been cited by the following article:

• TITLE: Possibilities of Experimental Modulation of Senescence by Stimulation of Antiradical Defense

  AUTHORS: Manuela Ciocoiu, Magda Badescu, Oana Badulescu, Madalina Mocanu, Codruta Badescu

  KEYWORDS: Senescence, Zinc Aspartate, Aronia melanocarpa, Oxidative Stress

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.8 No.4, April 8, 2015

  ABSTRACT: Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of neurodegenerative, hepatic diseases. The research aimed to fight oxidative stress and lipid metabolism changes in the context ofadministrationof antioxidants, such as polyphenolic extract of Aronia melanocarpa and zinc aspartate, known for its neurotrophic effects in intrinsic aging processes. Zinc aspartate and poly-phenolic extract from Aronia melanocarpa reduce oxidative stress values both in serum, liver homogenate, and in brain homogenate. Oxidative stress assessed by malondialdehyde (MDA), glutathione peroxidase (GPx) and total antioxidant capacity (TAC) markers was reduced in animals receiving additional zinc salts and polyphenolic extract of Aronia melanocarpa, which underlines their role in antioxidant defense. This combination produces more superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental senescence induced in the murine model. Further studies will investigate the effect of different dose combinations of zinc aspartate and polyphenolic extract of Aronia melanocarpa at different periods of treatments on age-associated liver/cerebral dysfunction.