TITLE:
Autoantibodies in Systemic Lupus Erythematosus, on Black African Subject, in Abidjan
AUTHORS:
Mariam Gbané-Koné, Baly Ouattara, Kouassi Jean Mermoz Djaha, Estelle Megne, Astrid Nawé Ngandeu, Abidou Kawalé Coulibaly, Edmond Eti, Marcel N’zué Kouakou
KEYWORDS:
Sub-Saharan Africa, Systemic Lupus Erythematosus, Extractable Nuclear Anti-Antigens, Autoantibodies, Anti-Phospholipids Autoantibodies, ELISA
JOURNAL NAME:
Open Journal of Rheumatology and Autoimmune Diseases,
Vol.5 No.2,
April
8,
2015
ABSTRACT: Aim: To determine the clinical and immunological characteristics of patients with systemic erythematosus lupus in Abidjan. Patients and Method: We studied 117 patients’ files with systemic lupus erythematosus aged 12 to 73 years old, who fulfilled the American College of Rheumatology (ACR)’s criteria. Antinuclear autoantibodies (ANA) were searched by indirect immunofluorescence. Anti-DNA native autoantibodies, extractable nuclear anti-antigens autoantibodies (anti-Sm, anti-SSA, anti-SSB and anti-RNP) and anti-phospholipids autoantibodies have been searched by ELISA technic. Results: The most frequent clinical manifestations were: articular damages (86.32%), cutaneous and mucosal lesions (71.79%) and fever (76.67%). Kidney damages have been noticed in 40.17%. Neurologic manifestations have been observed in 36.75%. Pericarditis and pleurisies have been noticed in 22.22% and 11.97% of cases, and anaemia in 86.32% of cases. ANA have been detected in 94.12% of cases, anti-DNA native’s autoantibodies in 73.53% and anti-Sm autoantibodies in 75% of cases. Anti-SSA and anti-SSB autoantibodies were respectively in 75% and 56.25% of cases. Anti-RNP autoantibodies were in all the patients, and anti-phospholipids autoantibodies were in 37.50% of cases. Conclusion: Systemic lupus erythematosus of Ivorian black subject is characterised by high prevalence of autoantibodies, mostly Anti-RNP.