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C. Kubo, A. Gajjar, B. C. Johnson and R. A. Good, “The Effects of Dietary Restriction on Immune Function and Development of Autoimmune Disease in BXSB Mice,” Proceedings of National Academy of Sciences U. S. A., Vol. 89, No. 7, 1992, pp. 3145-3149.

has been cited by the following article:

• TITLE: Intermittent Fasting Ameliorates Delayed-Type Hypersensitivity in NC/Nga Mice

  AUTHORS: Hirao Kohno, Katsuyasu Kouda, Hiroyasu Ishihara, Nobuhiro Nishio, Yutaka Sasaki, Harunobu Nakamura, Masayuki Iki, Yoshiaki Sonoda

  KEYWORDS: Intermittent Fasting, Delayed-Type Hypersensitivity, Contact Dermatitis, Thymocyte

  JOURNAL NAME: Food and Nutrition Sciences, Vol.2 No.4, June 14, 2011

  ABSTRACT: It is well documented that dietary restriction can prevent many different diseases and extend the life spans of different rodent species. In the previous study, we reported that intermittent fasting (IF) as well as moderate dietary restriction ameliorated the allergic dermatitis in ICR mice. In the present study, we demonstrated the ameliorative effects of IF on allergic dermatitis in NC/Nga mice, a strain known as a model for atopic dermatitis. Interestingly, the total number of CD4+CD8+ double positive thymocyte in mice after IF significantly decreased in comparison to that in mice fed ad libitum. Although it was reported that an immunosuppressive compound inhibited the contact allergic response by inducing the CD4+CD25+ regulatory T-cells, IF did not affect regulatory T cells in the present study. These results suggested that CD4+CD8+ double positive thymocytes play an important role in the regulation of allergy by IF in NC/Nga mice.