TITLE:
Mathematical Modeling of the Amperometric Response to Glucose of Glucose Oxidase Films Deposited by AC-Electrophoresis
AUTHORS:
Jan Fransaer, Malika Ammam
KEYWORDS:
Alternating Current Electrophoretic Deposition, Glucose Oxidase, Modeling
JOURNAL NAME:
Journal of Sensor Technology,
Vol.1 No.2,
June
29,
2011
ABSTRACT: Previous work illustrated that glucose oxidase (GOx) could be deposited on conducting substrates using asymmetrical alternating current electrophoretic deposition (AC-EPD) to form thick enzyme layers suitable for the manufacturing of highly active biosensors. Here, we modeled the amperometric response of GOx layers to glucose as a function of the thickness of the enzyme layer. The model is based on reaction-diffusion equations with irreversible first-order catalytic reactions. The numerical results displayed qualitative and reasonable quantitative agreement with the experimental data obtained for oxidation currents due to glucose, which increase with the enzyme thickness.