TITLE:
Antioxidant Activities and Inhibitory Effects of Auricularia Auricular and Its Functional Formula Diet Against Vascular Smooth Muscle Cell in Vitro
AUTHORS:
Yangchao Luo, Zhenlei Xiao, Qin Wang, Bo Li, Baoping Li
KEYWORDS:
Functional Diet, Auricularia Auricula, Antioxidant Activity, Vascular Smooth Muscle Cells, Serum Pharmacology
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.2 No.4,
June
14,
2011
ABSTRACT: The functional formula diet AHP, containing polysaccharides from Auricularia auricular, polyphenolic compounds from Hawthorn (Crataegus) and Pueraria radix, has been recently developed as a dietary intervention against dyslipidemia in our previous study. In the present study, its antioxidant activities and protective effects against proliferation of vascular smooth muscle cells (VSMCs) were investigated. AHP possessed the potent radical-scavenging effects against hydroxyl and superoxide radicals, and also the inhibitory effects against peroxidation of low density lipoprotein induced by Cu2+ in vitro. The protective effects of AHP against proliferation of VSMCs were evaluated through the methodology of serum pharmacology. The serum containing AHP significantly inhibited the proliferation of VSMCs induced by oxidized low density lipoprotein in a time- and dose-dependent manner, and also promoted the nitric oxide production of VSMCs. Our study indicated that this functional formula diet would be a potent alternative as a functional diet to prevent atherosclerosis at early stage.