TITLE:
LPS Regulates Apolipoprotein E and Aβ Interactionswith Effects on Acute Phase Proteins and Amyloidosis
AUTHORS:
Ian James Martins
KEYWORDS:
Lipopolysaccharides, Apolipoprotein E, Amyloid Beta, Acute Phase Protein, Diet
JOURNAL NAME:
Advances in Aging Research,
Vol.4 No.2,
March
27,
2015
ABSTRACT: Interactions between apolipoprotein E (apo E) and amyloid beta (Aβ) are associated with the peripheral
clearance of Aβ and are important to
the development of neurodegenerative diseases. Interests in acute phase
proteins (APP) as biomarkers for the early progression of Alzheimer’s disease
indicate that the peripheral Aβ metabolism is perturbed and the role of nutritional diets are important to
reduce APPs to maintain peripheral Aβ clearance with relevance to hepatic cholesterol homeostasis and brain
amyloidosis. The role of nutriproteomic diets that reverse the effects of high
fat diets are associated with the reduction in APPs, cholesterol homeostasis
and improved clearance of Aβ. Nutritional
diets that reduce the increase in plasma endotoxins (gut microbiotica) such as
lipopolysaccarides (LPS) reduce the effects of LPS on cell membranes and
increase the cellular uptake of Aβ by
interactions with apo E. LPS alter hepatic lipid metabolism with an increase
hepatic cytokines and APPs in plasma. Interactions between apo E and Aβ are altered by LPS with increased
binding of LPS to apo E with effects on electrostatic alterations in Aβ oligomers. The role of LPS in
neurodegenerative diseases includes the effects of LPS on alpha-synuclein metabolism
with relevance to Parkinson’s disease and Alzheimer’s disease