Article citationsMore>>

Rashad, A.E., Mahmoud, A.E. and Ali, M.M. (2011) Synthesis and Anticancer Effects of Some Novel Pyrazolo[3,4-d]-pyrimidine Derivatives by Generating Reactive Oxygen Species in Human Breast Adenocarcinoma Cells. European Journal of Medicinal Chemistry, 46, 1019-1026.
http://dx.doi.org/10.1016/j.ejmech.2011.01.013

has been cited by the following article:

• TITLE: A Novel One-Pot and Efficient Procedure for Synthesis of New Fused Uracil Derivatives for DNA Binding

  AUTHORS: Bothaina A. Mousa, Ashraf H. Bayoumi, Makarem M. Korraa, Mohamed G. Assy, Samar A. El-Kalyoubi

  KEYWORDS: 6-Chloro-1-methyluracil, Pyrazolo[3, 4-d]pyrimidines, 6-Aminouracils, Xanthine, Indenopyrrolopyrimidine and Indenopteridine

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.5 No.1, March 27, 2015

  ABSTRACT: Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the respective hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives. Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin respectively. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA.