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Bhonde, M.R., Hanski, M.L., Notter, M., Gillissen, B.F., Daniel, P.T., Zeitz, M., et al. (2006) Equivalent Effect of DNA Damage-Induced Apoptotic Cell Death or Long-Term Cell Cycle Arrest on Colon Carcinoma Cell Proliferation and Tumour Growth. Oncogene, 25, 165-175.

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• TITLE: Evaluating the p-FOXO1/FOXO1 Ratio: An Alternative Strategy for Endometrial Cancer Diagnosis

  AUTHORS: Mohsen Korani, Soudabeh Fallah

  KEYWORDS: Endometrial Cancer, FOXO1, p-FOXO1, Transcription Factor

  JOURNAL NAME: International Journal of Clinical Medicine, Vol.6 No.3, March 26, 2015

  ABSTRACT: Background: The FOXO subfamily of Forkhead transcription factors plays a central role in pro-moting expression of proapoptotic and cell cycle regulatory genes. FOXO1 expression has an im-portant role in human endometrium homeostasis. Therefore, reduced FOXO1 protein and its inactivation by phosphorylation might, play a role in progression of human endometrial cancer. Methods: Current study was designed to investigate the changes of the FOXO1, phosphorylated-FOXO1 (p-FOX1) proteins levels and the p-FOXO1/FOXO1 ratio in 30 patients with endometrial cancer and 20 subjects with normal endometrium, surgically using excised human endometrial tissue specimens, quantitative real time PCR and western blot methods. Results: FOXO1 protein level in patients with endometrial cancer significantly reduced in comparison with control group (0.17 ± 0.15 vs. 1 ± 0.14; p