TITLE:
Antidiabetic Effects of Omega-3 Polyunsaturated Fatty Acids: From Mechanism to Therapeutic Possibilities
AUTHORS:
Yuko Iwase, Noriyasu Kamei, Mariko Takeda-Morishita
KEYWORDS:
Omega-3 Polyunsaturated Fatty Acids, Diabetes, Insulin Secretion, Docosahexaenoic Acid
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.6 No.3,
March
24,
2015
ABSTRACT: Diabetes mellitus (DM) is chronic disease characterized by hyperglycemia and insulin resistance caused by dysfunction of pancreatic β cells. Over the past few decades, epidemiological studies have suggested that dietary long-chain polyunsaturated fatty acids such as docosahexaenoic acid and eicosapentaenoic acid decrease the risk of metabolic diseases including DM. The mechanisms underlying the therapeutic efficacy of dietary long-chain polyunsaturated fatty acids in treating DM have been partly revealed. In this review, the authors describe the antidiabetic effects of long-chain polyunsaturated fatty acids and also discuss their possibilities as therapeutics for DM in the light of recent findings.