TITLE:
A Facile and Inexpensive Synthesis of 6-Ethynylbipyridine
AUTHORS:
Jianqiang Huo, John O. Hoberg
KEYWORDS:
6-Ethynylbipyridine, 2-Bromo-6-Iodopyridine, 2-Methyl-3-Butyne-2-Ol, Palladium Coupling
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.1 No.2,
June
30,
2011
ABSTRACT: An inexpensive synthesis of 6-ethynylbipyridine has been accomplished using Sonogashira coupling of 2-bromo-6-iodopyridine with 2-methyl-3-butyn-2-ol. Subsequent Stille coupling with 2-(trimethylstannanyl) pyridine and hydrolysis provided the target compound in an overall high yield.