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M. Perez, J. Soto, "Synthesis of 6-Alkoxy-2-amino-5-cyanopyrimidines through sodium Alkoxide-Induced Regiospecific Cyclization of 1,3-Dicarbonitriles’’, Synthesis, Vol 12, 1981, pp. 955-958.

has been cited by the following article:

• TITLE: A Facile Synthesis of 2-Amino-5-Cyano-4, 6-Disubstitutedpyrimidines under MWI

  AUTHORS: Kishor S. Jain, Swapnil. K. Chaudhari, Nikhil S. More, Kapil D. More, Sachin A Wakedkar, M. K. Kathiravan

  KEYWORDS: Microwave Assisted Organic Synthesis (MAOS), 2-Amino-5-Cyano-2, 6-Disubstitutedpyrimidines, Α-Cyanoketene S, S-Acetals

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.1 No.2, June 30, 2011

  ABSTRACT: Microwave Assisted Organic Synthesis (MAOS) is energy efficient and effective tool to speed up the synthesis for drug discovery process. In the present study we report a novel protocol for the rapid, high throughput synthesis of mononuclear 2-amino-5-cyano-4,6-disubstituted pyrimidines, adaptable to parallel synthesis for compound libraries. The overall reaction time in hrs has been reduced to 25 - 50 minutes with improved yields.