TITLE:
Radiated Ultrashort High-Power Electromagnetic Pulses Induce ATP Release in B16F10 Murine Melanoma Cells
AUTHORS:
Sabrina Macaire, Alexandre Catrain, Stéphane Tortel, Jean-Christophe Joly, Sébastien Girard, Pierre Bonnet, Alain Vian
KEYWORDS:
Radiated Electromagnetic Pulses, Koshelev Antenna, eATP, Cell Viability
JOURNAL NAME:
Journal of Electromagnetic Analysis and Applications,
Vol.7 No.3,
March
19,
2015
ABSTRACT: Ultrawideband
electromagnetic pulses with high amplitude and short duration are reported to
affect several aspects of cell physiology. They are usually delivered to the
living material through electrodes in small dedicated chambers. Here we showed,
using a totally different experimental setup, that radiated EM pulses
illuminating the living material through a specialized antenna (without any
direct contact) are able to trigger a rapid release of ATP in cultured murine
cells that was concomitant with a drop of intracellular AEC. Despite this rapid
and strong response, we found that cell viability and clonogenicity were only
slightly affected by the EMF exposure.