TITLE:
3D Numerical Simulation of Epidermal Skin Turnover Process Using a Particle Model
AUTHORS:
Katsuya Nagayama, Takahiro Uehara, Yasuko Amano, Masanori Tanahashi
KEYWORDS:
Numerical Simulation, Skin Formation, Particle Model
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.3,
March
18,
2015
ABSTRACT: Skin is the largest organ of the human
body. In recent years, concern regarding the cosmetics area has increased, and
research studies on anti-aging therapy or cosmetics have been rapidly conducted.
Skin cells are not only changing its shape but also its physical properties
during the epidermal skin turnover process. Computational simulation can be useful
in further understanding the mechanisms of skin formation. We propose a
particle model that can handle complex biological phenomena, including cell
interactions and is a suitable method for simulating skin formation. The
particle model was applied to simulate three-dimensional skin formation
accompanied by proliferation and cornification of skin cells. The simulation
results represented and reproduced the epidermal skin turnover phenomenon.