TITLE:
Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene
AUTHORS:
Wei Qu, Fang Zhang
KEYWORDS:
Styrene, Mandelic Acid (MA), Phenylglyoxylic Acid (PGA), Phenyl Hydroxyethyl Mercapturic Acids (PHEMA), Biological Monitoring, Genetic Polymorphisms
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.3 No.3,
March
18,
2015
ABSTRACT: In this study, we selected 58
styrene-exposed workers, measured personal styrene exposure, evaluated genotypes
relevant drug-metabolizing enzymes (CYP2E1, EPHX1, GSTM1 and GSTT1) which may
explain the variability in the urinary metabolite excretion. The results showed
that, in different levels of styrene exposure groups, there is a significant association
between urinary metabolites and some genotypes of styrene-metabolizing enzymes,
including CYP2E1 (5-flanking region, RsaI/PstI), GSTM1(gene deletions) and EPHX1(predicted
activity).