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Higgs, S. and Cooper, S.J. (2000) The effect of the dopamine D2 receptor antagonist raclopride on the pattern of licking microstructure induced by midazolam in the rat. European Journal of Pharmacology, 409, 73-80. doi:10.1016/S0014-2999(00)00802-5

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• TITLE: Antidepressant and cognitive activities of intranasal piperine-encapsulated liposomes

  AUTHORS: Aroonsri Priprem, Pennapa Chonpathompikunlert, Saengrawee Sutthiparinyanont, Jintanaporn Wattanathorn

  KEYWORDS: Piperine Liposome; Anti-Depression Activity; Cognitive Enhancement Effect; Intranasal Route

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.2 No.2, April 8, 2011

  ABSTRACT: Antidepressant and cognitive effects of piperine -encapsulated liposomes (PL) were investigated in male Wistar rats. Oral piperine (5 mg/kg body weight/day) and intranasal PL (7.2 µg/day) were randomly assigned to daily administer for 14 days to rats which were subjected to forced swimming, Mor-ris water maze and spontaneous motor behavior tests. PL significantly exhibited anti-depression like activity and cognitive enhancing effects, in comparison to the control groups after the first dose (p