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Vyas, S.P., Bhatnagar, S., Gogol, P.J. and Jain, N.K. (1991) Preparation and characterization of HSA propranolol microspheres for nasal administration. International Journal of Pharmaceutics, 69, 5-12. doi:10.1016/0378-5173(91)90081-X

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• TITLE: Antidepressant and cognitive activities of intranasal piperine-encapsulated liposomes

  AUTHORS: Aroonsri Priprem, Pennapa Chonpathompikunlert, Saengrawee Sutthiparinyanont, Jintanaporn Wattanathorn

  KEYWORDS: Piperine Liposome; Anti-Depression Activity; Cognitive Enhancement Effect; Intranasal Route

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.2 No.2, April 8, 2011

  ABSTRACT: Antidepressant and cognitive effects of piperine -encapsulated liposomes (PL) were investigated in male Wistar rats. Oral piperine (5 mg/kg body weight/day) and intranasal PL (7.2 µg/day) were randomly assigned to daily administer for 14 days to rats which were subjected to forced swimming, Mor-ris water maze and spontaneous motor behavior tests. PL significantly exhibited anti-depression like activity and cognitive enhancing effects, in comparison to the control groups after the first dose (p