TITLE:
Intratympanic Injections: An Unsolved Mystery
AUTHORS:
Kartik Parelkar, Vandana Thorawade, Mohan Jagade, Smita Nagle, Rajanala Nataraj, Madhavi Pandare, Reshma Hanwate, Bandu Nagrale, Kiran Kulsange, Devkumar Rangaraja, Arpita Singhal
KEYWORDS:
Intratympanic Injection, Round Window, Tinnitus, Dexamethasone
JOURNAL NAME:
International Journal of Otolaryngology and Head & Neck Surgery,
Vol.4 No.2,
March
12,
2015
ABSTRACT: Aims: The aim of this study was to test the effectiveness of intratympanic dexamethasone injections as a treatment for severe disabling tinnitus and also observe its effect on hearing loss if any. Materials and Methods: Thirty patients with severe disabling tinnitus in the age group 20 to 60 years were selected and randomly assigned to receive intratympanic injections of a dexamethasone solution 4 mg/ml (0.5 ml) or isotonic saline (0.5 ml) solution under topical anaesthesia, once per week for 4 weeks using a zero degree endoscope. Improvement in tinnitus was assessed using a visual analog scale, considering 2-point improvement as significant and alteration in hearing if any was noted by pure tone audiometery before and after the therapy. Results: The improvement in tinnitus was not significant, with no alteration in audiometery reports. Conclusions: Intratympanic therapy is an attractive mode of treatment because of its highly targeted delivery, low concentration of the drugs required and a very good patient tolerance. Although there has been no breakthrough in intratympanic therapy for tinnitus or other otological conditions, accessibility to the inner ear through the semipermeable round window membrane holds many promises in the near future.