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Nam, Y.H., Min, D., Kim, H.P., Song, K.J., Kim, K.A., Lee, Y.A., Kim, S.H., Lee, Y.A., Kim, K.A., Song, K.J. and Shin, M.H. (2011) Leukotriene B4 Receptor BLT-Mediated Phosphorylation of NF-κB and CREB Is Involved in IL-8 Production in Human Mast Cells Induced by Trichomonas vaginalis-Derived Secretory Products. Microbes and Infection/Institut Pasteur, 13, 1211-1220.

has been cited by the following article:

• TITLE: Kinetics of Serum and Local Leukotriene B4 Response in Experimental Intravaginal Trichomoniasis by T. vaginalis Isolates from Symptomatic and Asymptomatic Women

  AUTHORS: Amany M. Eida, Omima M. Eida, Ahmed Saied Salem

  KEYWORDS: Trichomoniasis, Clinical Isolates, Experimental Study, Pathogenesis, Immune Response, Leukotriene B4

  JOURNAL NAME: Advances in Infectious Diseases, Vol.5 No.1, February 28, 2015

  ABSTRACT: Trichomoniasis is most common sexually transmitted disease caused by T. vaginalis. The clinical manifestation varies from severe manifestation to asymptomatic condition. However, the exact virulence markers led to varied symptomatology was not well clarified. The role of leukotriene B4 (LTB4) in the pathogenesis of many parasitic diseases has been reported. The present study reports the leukotriene B4 levels on different days post infection (3rd, 7th, 14th, 21st and 28th d.p.i.) in serum and vaginal washes (VWs) and vaginal tissues of mice infected intravaginally with T. vaginalis isolates from 10 symptomatic and 10 asymptomatic women. A significant increase in LTB4 was observed on the 3rd to 28th d.p.i. in serum and VWs of mice infected with T. vaginalis isolates from asymptomatic as compared to symptomatic women. The present study also reports the histopathological changes of the posterior vaginal fornix’s and upper portion of the vagina of mice infected intravaginally with T. vaginalis isolates from 10 symptomatic and 10 asymptomatic women. The results show that there are no significant differences between symptomatic and asymptomatic isolates regarding histopathological changes.