TITLE:
Re-Parameterization the Logistic Model in Assessing Changes in the Baroreceptor Reflex
AUTHORS:
Shande Chen, Xiangrong Shi
KEYWORDS:
blood pressure, carotid sinus pressure, heart rate, mathematical model, maximum gain, nitroprusside, operating range
JOURNAL NAME:
Neuroscience and Medicine,
Vol.2 No.2,
June
29,
2011
ABSTRACT: The logistic model is frequently used to describe the nonlinear relationship between systemic arterial pressure (SAP) and carotid sinus pressure (CSP). In this paper, we propose using maximum gain and saturation as parameters in the logistic model. By this method, the estimates and standard errors together with confidence intervals for maximum gain and saturation are direct outputs from the curve fitting, which also makes it easy to perform various hypotheses testing on these quantities. The method is illustrated by real life data from a study on the carotid baroreflex function during infusion of sodium nitroprusside, in which seven healthy, young men who were clinically proved to be free from any disease were studied. Their heart rate, arterial blood pressure and central venous pressure were measured. Neck pressure and neck suction protocol was carried out to selectively elicit changes in CSP and the responsiveness of SAP. Data were analyzed and compare before and after nitroprusside infusion. Our results showed that nitroprusside significantly decreased arterial blood pressure and central venous pressure, and significantly increased heart rate, and significantly augmented maximum gain of the carotid baroreflex function.