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Vetting, M.W., Park, C.H., Hegde, S.S., Jacoby, G.A., Hooper, D.C. and Blanchard, J.S. (2008) Mechanistic and Structural Analysis of Aminoglycoside N-Acetyltransferase AAC(6’)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6’)-Ib-cr Variant. Biochemistry, 47, 9825-9835.
http://dx.doi.org/10.1021/bi800664x

has been cited by the following article:

• TITLE: Increasing Incidence of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae (ESBL) and the Relation to Consumption of Broad-Spectrum Antimicrobial Agents 2003-2011 in a Large Area of Copenhagen, Denmark

  AUTHORS: Lene Nielsen, Anne Kjerulf, Magnus Arpi

  KEYWORDS: Incidence of ESBL-Producing E. coli and K. pneumoniae, Hospital Care, Primary Health Care, Antimicrobial Consumption, Broad-Spectrum Antimicrobial Agents

  JOURNAL NAME: Open Journal of Medical Microbiology, Vol.5 No.1, March 5, 2015

  ABSTRACT: Purpose: To investigate 1) the development in the incidence of ESBL-producing bacteria in hospitals and primary health care, 2) the contribution of primary health care to the incidence of ESBL-producing bacteria, and 3) the development in resistance patterns for all Escherichia coli and Klebsiella pneumoniae isolates in relation to antimicrobial consumption in hospitals and primary health care. Methods: ESBL-data were retrospectively collected from bacterial isolates from all specimens received at the Department of Clinical Microbiology from 2003 to 2011 together with the corresponding patient data. ESBL-production was detected in isolates from 1067 of 59,373 patients (1.8%) with an E. coli infection and in 263 of 8660 patients (3.0%) with a K. pneumoniae infection. Results: From 2003 to 2009, an increase in patients with an ESBL-producing isolate occurred in both hospitals and primary health care at the same time as an increased consumption of broad-spectrum antimicrobial agents was seen. Interventions to reduce prescription of cephalosporins and ciprofloxacin at the hospitals from 2010 resulted in a remarkable decrease in patients with ESBL-producing K. pneumoniae whereas a continuing increase was seen in patients with ESBL-producing E. coli both at hospitals and in primary health care. The proportion of patients with community-acquired ESBL-producing E. coli was stable with an increase of only 1.4% from 2007 to 2011. Conclusions: Reduction in prescription of broad-spectrum antimicrobial agents at the hospital level had an important impact on the incidence of ESBL-producing K. pneumoniae, but not on ESBL-producing E. coli.