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Domaschke, H., Gelinsky, M., Burmeister, B., Fleig, R., Hanke, T., Reinstorf, A., Pompe, W. and Rosen-Wolff, A. (2006) In Vitro Ossification and Remodeling of Mineralized Collagen I Scaffolds. Tissue Engineering, 12, 949-958.

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• TITLE: Bioinspired-Interpenetrating Network (IPNs) Hydrogel (BIOF-INPs) and TMD in Vitro: Bioadhesion, Drug Release and Build in Free Radical Detection and Defense

  AUTHORS: Victoria Tamara Perchyonok, Vanessa Reher, Nicolaas J. Basson, Shengmiao Zhang, Sias R. Grobler

  KEYWORDS: TMD, Functionalized IPNs, Bio-Adhesion, Drug Release, Build in Free Radical Detection and Defense

  JOURNAL NAME: Open Journal of Stomatology, Vol.5 No.3, March 4, 2015

  ABSTRACT: In this work, Bioactive-functionalized interpenetrating network (IPNs) hydrogel (BIOF-INPs) were prepared and investigated in vitro for the free radical detection/defense, therapeutic release as well as shear bond strength to dentine, ability to re-mineralize surface of the dentin after application of these bio-inspired materials using a biologically inspired mineralization process in vitro as well as investigating antimicrobial properties of the BIOF-INPs against S. aureous. The aim of this investigation was to evaluate the suitability and flexibility of the designer materials to act as an “in vitro” probe to gain insights into molecular origin of TMD and associated disorders.