TITLE:
The Association between Chlamydia Trachomatis and Ectopic Pregnancy in Lagos, Nigeria—A Case Control Study
AUTHORS:
A. A. Adewunmi, O. O. Orekoya, K. A. Rabiu, T. A. Ottun
KEYWORDS:
Chlamydia trachomatis, Ectopic Pregnancy, Seropositivity, Risk Factors
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.5 No.2,
February
16,
2015
ABSTRACT: Objectives: To determine the seropositivity of Chlamydia antibody
in patients with ruptured ectopic pregnancy compared to normal pregnant women
and the risk factors for ectopic pregnancy. Study Design: This was a
prospective case-control study of 85 cases of ruptured ectopic pregnancy and
100 cases of second trimester on-going intrauterine pregnant controls
presenting in Lagos State University Teaching Hospital (LASUTH) between
September 2009 and March 2010. Study Site: This was at the gynaecological
emergency room and antenatal clinic in the Department of Obstetrics and
Gynaecology. Ethical approval was sought and granted by the ethics review
committee of LASUTH. Study Participants: Patients presenting with ruptured
ectopic pregnancy were recruited as cases while the controls were made up of
those with uncomplicated second trimester intrauterine pregnancy. A
semi-structured questionnaire containing socio-demographic and clinical
characteristics was administered following informed consent. Five milliliters
of venous blood was taken from each participant and tested forLymphogranuloma
Venerum(LGV) type 2 broadly reacting antigen ofChlamydia trachomatis.Data
Analysis: Data gathered from the case notes and laboratories were imputed into
the computer and analyzed using the statistical packageEpi-Info 3.51, Atlanta, USA. Frequency tables were
generated for continuous variables andchi-square
analysis used to determine association between variables, with p values
postabortal/puerperal sepsis (p = 0.013). The
seropositivity ofChlamydia
IgG (62.4%) in the cases was significantly higher than that of 29% in the
control (p