TITLE:
Auto-presentation of Staphylococcal enterotoxin A by mouse CD4+ T cells
AUTHORS:
Reuven Rasooly, Paula M. Do, Bradley J. Hernlem
KEYWORDS:
MHC Class II; T-Cell; Enterotoxin
JOURNAL NAME:
Open Journal of Immunology,
Vol.1 No.1,
June
30,
2011
ABSTRACT: The currently accepted model for superantigen (SAg) induced T cell activation suggests that SAg, without being processed, cross link both MHC class II, from Antigen Presenting Cells (APC), and V-β , from T-cell receptor (TCR), initi-ating nonspecific T-cell activation. This T-cell proliferation induces a massive cytokine release associated with several human diseases. It is thought that murine CD4+ T cells do not express MHC class-II molecules. However, we discov-ered that a subtype of mouse naïve CD4+ T cells expresses MHC class II on their cell surface and that these CD4+ T cells can perform the role of both APC and T cells, able to present Staphy-lococcal enterotoxin A (SEA) to itself or neigh- boring CD4+ T cells via MHC class II, thus in-ducing massive CD4+ T cell proliferation. Treat- ment with neutralizing anti MHC class II anti-body inhibits this CD4+ T cell proliferation re-sponse. The fact that murine CD4+ T cells ex-press MHC class II offers new insight about SAg activity. Based on our findings, we propose re-vising and extending previous models for SAg induced T cell activation, altering previous models of MHC class II restriction of T cell re-sponses to SEA as well as the requirement for SAg processing.