TITLE:
Messages from the Border: Novel Insights in Signal Transduction Pathways Involved in Tumor Invasion and Metastasis
AUTHORS:
Michele Ciccarelli, Mariarosaria Rusciano, Daniela Sorriento, Angela Serena Maione, Maria Soprano, Guido Iaccarino, Maddalena Illario
KEYWORDS:
Metastasis, Angiogenesis, miRNA, GRKs, CaMKs
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.2,
February
11,
2015
ABSTRACT: Cancer is a multistep process encompassing the
transformation of normal epithelial cells to the stromal invasion and
metastasis, with these last considered the final stage of the disease. Tumor
invasiveness is based on creation of a specific peri-tumoral environment which
on turn depends upon epithelial-stromal interactions, degradation of
extracellular matrix and reorganization of fibrillar components. Even though
several aspects of the stromal and cellular remodeling have been elucidated and
described, such as the epithelial-mesenchymal transition (EMT) and
extracellular matrix degradation, all the underlying molecular mechanism are
far to be elucidated in their complexity. In this review we focused on new
actors such as microRNAs, G protein coupled receptor kinases (GRKs) and
Calcium/calmodulin-dependent protein kinase (CaMKs) known to be involved in
several important physiological processes like development, cell
differentiation and cell signaling, and more recently linked to tumor
progression and invasion.