TITLE:
Cancers in Children Ages 8 to 12 Are Injury-Related
AUTHORS:
Kirsten H. Walen
KEYWORDS:
Endomitosis, Endotetraploidization, Diplochromosomes, Reductive Division, Genomic Change, Proliferative Advantage, Wound Healing
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.2,
February
9,
2015
ABSTRACT: Cancers in young children in early
growing age was a short PBS (KQED) report (11/21/2014), but without
informational source, which prompted a Google search. Sports-associated
injuries with medical healing treatments concluded that there were no
association between these body traumas and cancer development. But there are
other activities from young children, such as “dare-devil” skateboard and
bicycling meter-high jumping with potential high energy falls, to serious
broken-bone injuries. Falls of children are among the most common causes of US
emergency response. The question is why bodily injury is associated with
cancer-development? An answer to this question was exemplified by osteosarcoma
in young children, which suggested that injury to growing points of bone and
surrounding soft tissue cells would elicit a repair process (wound healing
process) producing polyploidy with diplochromosomes. The non-mitotic reductive
division of such 4-chromatid chromosomes has been shownin vitroto produce pathological cancer-like
phenotypes, including gain of a proliferative advantage.