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Heng, H.H., Bremer, S.W., Stevens, J.B., Horne, S.D., Liu, G., Abdallah, B.Y., Ye, K.J. and Ye, C.J. (2013) Chromosomal Instability (CIN): What It Is and Why It Is Crucial to Cancer Evolution. Cancer and Metastasis Reviews, 32, 325-340. http://dx.doi.org/10.1007/s10555-013-9427-7

has been cited by the following article:

• TITLE: Cancers in Children Ages 8 to 12 Are Injury-Related

  AUTHORS: Kirsten H. Walen

  KEYWORDS: Endomitosis, Endotetraploidization, Diplochromosomes, Reductive Division, Genomic Change, Proliferative Advantage, Wound Healing

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.2, February 9, 2015

  ABSTRACT: Cancers in young children in early growing age was a short PBS (KQED) report (11/21/2014), but without informational source, which prompted a Google search. Sports-associated injuries with medical healing treatments concluded that there were no association between these body traumas and cancer development. But there are other activities from young children, such as “dare-devil” skateboard and bicycling meter-high jumping with potential high energy falls, to serious broken-bone injuries. Falls of children are among the most common causes of US emergency response. The question is why bodily injury is associated with cancer-development? An answer to this question was exemplified by osteosarcoma in young children, which suggested that injury to growing points of bone and surrounding soft tissue cells would elicit a repair process (wound healing process) producing polyploidy with diplochromosomes. The non-mitotic reductive division of such 4-chromatid chromosomes has been shownin vitroto produce pathological cancer-like phenotypes, including gain of a proliferative advantage.