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Maserejian, N.N., Giovannucci, E.L., McVary, K.T. and McKinlay, J.B. (2011) Dietary, but Not Supplemental, Intakes of Carotenoids and Vitamin C Are Associated with Decreased Odds of Lower Urinary Tract Symptoms in Men. Journal of Nutrition, 141, 267-273. http://dx.doi.org/10.3945/jn.110.132514

has been cited by the following article:

• TITLE: Two Grams BID Is an Oral Dosage of Vitamin C to Reduce the Risk of Recurrence of Superficial Bladder Carcinoma

  AUTHORS: Edward Folk, Tracy M. Downs, Alfred Roc Ordman

  KEYWORDS: Cancer, Vitamin C, LUTS, Superficial Bladder Carcinoma

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.2, February 9, 2015

  ABSTRACT: Background: Continuous exposure to millimolar (mM) Vitamin C (AA) in vitro kills cancer cells. For superficial bladder carcinoma (SBC), standard chemotherapy is instillation of Bacillus Calmette-Guerin. The recurrence rate with this therapy is 91%. But high dosage vitamins including AA reduced the recurrence to 41%. Aim: To determine the oral dosage of AA that causes the highest concentration of AA [AA] in the bladder. Method: We conducted a clinical trial of 14 people who took various dosages of AA, and analyzed the [AA] in their urine. Results: AA above 2 g twice a day was not absorbed. But that intake produced a bladder [AA] above 1 mM in all participants. Conclusion: Taking 2 g of AA BID will increase [AA] in the bladder to a level likely to kill cancer cells that cause SBC. Taking that dosage 2 consecutive days a week is likely to reduce the recurrence rate of SBC substantially.