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Lamm, D.L., Riggs, D.R., Shriver, J.S., van Gilder, P.F., Rach, J.F. and De Haven, J.I. (1994) Megadose Vitamins in Bladder Cancer: A Double-Blind Clinical Trial. Journal of Urology, 151, 21-26.

has been cited by the following article:

• TITLE: Two Grams BID Is an Oral Dosage of Vitamin C to Reduce the Risk of Recurrence of Superficial Bladder Carcinoma

  AUTHORS: Edward Folk, Tracy M. Downs, Alfred Roc Ordman

  KEYWORDS: Cancer, Vitamin C, LUTS, Superficial Bladder Carcinoma

  JOURNAL NAME: Journal of Cancer Therapy, Vol.6 No.2, February 9, 2015

  ABSTRACT: Background: Continuous exposure to millimolar (mM) Vitamin C (AA) in vitro kills cancer cells. For superficial bladder carcinoma (SBC), standard chemotherapy is instillation of Bacillus Calmette-Guerin. The recurrence rate with this therapy is 91%. But high dosage vitamins including AA reduced the recurrence to 41%. Aim: To determine the oral dosage of AA that causes the highest concentration of AA [AA] in the bladder. Method: We conducted a clinical trial of 14 people who took various dosages of AA, and analyzed the [AA] in their urine. Results: AA above 2 g twice a day was not absorbed. But that intake produced a bladder [AA] above 1 mM in all participants. Conclusion: Taking 2 g of AA BID will increase [AA] in the bladder to a level likely to kill cancer cells that cause SBC. Taking that dosage 2 consecutive days a week is likely to reduce the recurrence rate of SBC substantially.